Cairo is the capital of Egypt. The city's metropolitan area is one of the largest in Africa, the largest in the Middle East, and the 15th-largest in the world, and is associated with ancient Egypt, as the famous Giza pyramid complex and the ancient city of Memphis are located in its geographical area. Located near the Nile Delta, modern Cairo was founded in 969 CE by the Fatimid dynasty, but the land composing the present-day city was the site of ancient national capitals whose remnants remain visible in parts of Old Cairo. Cairo has long been a centre of the region's political and cultural life, and is titled "the city of a thousand minarets" for its preponderance of Islamic architecture. Cairo is considered a World City with a "Beta +" classification according to GaWC.

The area around present-day Cairo, especially Memphis that was the old capital of Egypt, had long been a focal point of Ancient Egypt due to its strategic location just upstream from the Nile Delta. However, the origins of the modern city are generally traced back to a series of settlements in the first millennium. Around the turn of the 4th century, as Memphis was continuing to decline in importance,the Romans established a fortress town along the east bank of the Nile. 

Cairo has the oldest and largest film and music industries in the Arab world, as well as the world's second-oldest institution of higher learning, Al-Azhar University. Many international media, businesses, and organizations have regional headquarters in the city; the Arab League has had its headquarters in Cairo for most of its existence.